Researchers Helia B. Schonthaler and Erwin Wagner of the National Cancer Research Centre (CNIO) show in a study in mice that antibodies that block VEGF protein, which are used as anti-cancer and could be used as an effective treatment for psoriasis. The study results are published in the online edition of the journal Proceedings of the National Academy of Sciences (PNAS).
The work, led by Schonthaler and performed mainly in the laboratory of Wagner in the CNIO, focuses on the protein vascular endothelial growth factor (VEGF) that plays a key role in the formation of blood vessels. The protein is present at high levels in psoriasis patches on the skin of people with the disorder. Furthermore, systemic levels of VEGF, such as the level of VEGF in the blood of patients appear to be higher with increasing severity of the disease.
According to Europa Press said Helia B. Schonthaler, “we saw an increase of VEGF with excessive formation of blood vessels in the skin of our mouse model of psoriasis. Using anti-VEGF antibody that blocks VEGF, symptoms similar to psoriasis in the skin of these mice was greatly reduced. For example, the thickness and inflammation of the skin almost to normal with a smaller number and size of blood vessels”. (more…)