National Nursing Review : Nursing Study Resources & Health Tips

Substance normally present in blood and coming for 80 to 85% from hemoglobin in red blood cells and when these, after 120 days on average, arrive at the end of their useful lives are destroyed in the spleen and the heme in hemoglobin is converted in bilirubin.
An other dimension is, 10-15% is produced directly from bone marrow during a process of ineffective erythropoiesis, while the remaining 5% is formed in the liver and is then poured into the intestine.
Bilirubin is a substance to move so poorly soluble in an aqueous medium such as blood plasma, requires a carrier which turns out to be albumin.
This is called indirect bilirubin, and is the type that is more in the blood, while those that produced by the liver and is soluble in water. (more…)