Mechanisms of Action
Steroids alter the synthesis of proteins therefore alter:

  • Chemotaxis,
  • Metabolism
  • Expression (hormones, mediators).

Pharmacological Actions

Cortisol (hormone)
Corticosteroid (drug)
Anti-inflammatory effects,
Provide glucose to the brain,
Effects immuno-modulators,
Effects on carbohydrate
Effects on carbohydrate
Effects on lipids,
Effects on lipids,
Effects on protein
Effects on protein
Metabolic,
Effects on the brain
Cardiac effects.


Therapeutic Effects
Side Effects

Effects on carbohydrate
How to bring glucose to the brain?

Solutions Solutions Consequences
Harnessing the circulating glucose Fosters or worsens diabetes
Mobilize the reserves of glucose Weakness



Effects on lipids
How to bring glucose to the brain?

Solutions
Consequences
Turning fat into carbohydrate
Fat redistribution
Promotes heart disease type arteriosclerosis
Effects on protein
How to bring glucose to the brain?
Solutions
Consequences
Transforming protein carbohydrate
Fonts muscle
he risk of fracture

Effects on the brain
Effects Hard mood (euphoria, depression)
Behavioral effects (insomnia, agitation).

Cardiac effects
Are mainly a result of water retention and sodium, with risk of hypertension evolving slowly and increased sensitivity to vasopressor drugs.
There is also in blood hyperviscosity of blood.

Other effects
Digestive: the pro-ulcérigène.
Blood: increased red blood cell and hematocrit.
Growth: High-dose prolonged corticosteroids can slow or stop growth by acting on the active cells of cartilage.

Anti-inflammatory Effects
The steroids will destroy the antigen to reduce the chemotaxis of antibodies by creating swelling and vasodilation.

Immunosuppressive effects

  • Reduced number of circulating lymphocytes,
  • Partial inhibition of cell function of lymphocytes,
  • Decreased production of antibodies,
  • Decreased resistance to infection.

Indications for corticosteroids

“Asthma,
“Autoimmune diseases,
“Parasitic Diseases inflammatory effects predominate,
“Prevention of transplant rejection or transplantation (association),

Vital emergency:
© laryngeal edema,
© anaphylactic shock,
© Status asthmaticus,
© hypovolemic shock.
Cons indication
Absolute contraindications:
Ø gastric ulcer development,
Ø malignant hypertension,
Ø Serious Violations of viral,
Ø acute psychosis.
Contraindications for:
Ø Tuberculosis pulmonary
Ø Osteoporosis,
Ø Chronic glomerulonephritis,
Ø healed gastric ulcer.

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